Hydroxylamine hydrochloride
Synonym(s):Hydroxylamine hydrochloride;Hydroxylammonium chloride;Hydroxylammonium Chloride, Hydroxyl Ammonium Chloride
- CAS NO.:5470-11-1
- Empirical Formula: NH2OH·HCl
- Molecular Weight: 69.49
- MDL number: MFCD00051089
- EINECS: 226-798-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-24 08:56:47
What is Hydroxylamine hydrochloride?
Description
Hydroxylamine hydrochloride is a reducing agent that is routinely used for the deacetylation of SATA to form free sulfhydryls (Figure 1), for cleavage of protein cross‐linkers that contain carbonyl groups (i.e. EGS) and for mutagenesis of plasmid DNA.
Hydroxylamine converts aldehydes and ketones (carbonyls) to their oxime derivative in weak bases, therefore cross‐linkers and other compounds with carbonyl groups are cleavable with Hydroxylamine hydrochloride.
SATA and SATP are modification reagents that add a sulfhydryl group to primary amines on biomolecules. The initial modification results in the addition of an acetyl‐protected sulfur enabling storage of the biomolecule. To generate a free sulfhydryl the biomolecule is treated with hydroxylamine to remove the protecting acetyl group (see figure).
EGS and sulfo‐EGS are homobifunctional, succinimidyl ester, amine reactive crosslinkers that are resistant to cleavage by denaturants used in SDS‐PAGE conditions, but may be cleaved with hydroxylamine.
The Uses of Hydroxylamine hydrochloride
Hydroxylamine hydrochloride is a monomoamine oxidase inhibitor. It is used to prepare oximes and hydroxmic acids in organic synthesis. It acts as a copolymerization inhibitor. It can be used to remove bromine and polybromide from a solution during extraction of lignin from lignocellulosic biomass. It is key starting material for the preparation of pharmaceuticals and agrochemicals. It plays a vital role in rubber and plastic industries as an antioxidant, a vulcanization accelerator and a radical scavenger. It is also used as a color stabilizer and emulsion additive in color films.
What are the applications of Application
Hydroxylamine hydrochloride is an agent used as a catalyst and copolymerization inhibitor
Properties of Hydroxylamine hydrochloride
Melting point: | 155-157 °C (dec.)(lit.) |
Density | 1.67 g/mL at 25 °C(lit.) |
storage temp. | Store at +15°C to +25°C. |
solubility | 470g/l |
form | Liquid |
color | White to off-white |
Water Solubility | 560 g/L (20 ºC) |
Sensitive | Hygroscopic |
Safety information for Hydroxylamine hydrochloride
Signal word | Warning |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09 |
GHS Hazard Statements |
H290:Corrosive to Metals H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H351:Carcinogenicity H373:Specific target organ toxicity, repeated exposure H400:Hazardous to the aquatic environment, acute hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Hydroxylamine hydrochloride
InChIKey | WTDHULULXKLSOZ-UHFFFAOYSA-N |
Abamectin manufacturer
Vardhaman P Golechha
JSK Chemicals
Dhara Industries
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