HBTU
Synonym(s):N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate;O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate;2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate;HBTU
- CAS NO.：94790-37-1
- Empirical Formula: C11H16F6N5OP
- Molecular Weight: 379.25
- MDL number: MFCD00075445
- EINECS: 619-076-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-29 16:45:47
What is HBTU?
The Uses of HBTU
HBTU is a coupling reagent used in peptide synthesis. HBTU has been shown to effectively suppress racemization.
The Uses of HBTU
To a suspension of the amine (3.0 g, 11.4 mmol), the acid (2.88 g, 9.54 mmol), and TEA (4.81 mL, 34.5 mmol) in DMSO (30 mL) was added HBTU (4.34 g, 34.5 mmol). The reaction mixture was stirred at RT for 18 h, after which time it was diluted with EtOAc (100 mL), washed with H2O (100 mL), brine (3 x 100 mL), dried (Na2SO4), and concentrated to a brown solid. The resulting material was triturated in MTBE then EtOAc to provide the product. [3.97 g, 7.8 mmol]
What are the applications of Application
HBTU is a coupling reagent often used in solid phase peptide synthesis
Properties of HBTU
| Melting point: | 200 °C (dec.)(lit.) |
| Flash point: | 200°C |
| storage temp. | Store at +2°C to +8°C. |
| solubility | acetonitrile: 0.1 g/mL, clear |
| form | Powder |
| appearance | White crystalline solid |
| color | White to Off-White |
Safety information for HBTU
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for HBTU
| InChIKey | UQYZFNUUOSSNKT-UHFFFAOYSA-N |
Abamectin manufacturer
Litha Life Sciences Pvt Limited
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SYNGENESIS CHEMSCIENCE PRIVATE LIMITED
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