Fluticasone propionate
Synonym(s):(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester;Fluticasone propionate
- CAS NO.:80474-14-2
- Empirical Formula: C25H31F3O5S
- Molecular Weight: 500.57
- MDL number: MFCD00866007
- EINECS: 617-082-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-13 18:20:42
What is Fluticasone propionate?
Absorption
Intranasal bioavailability of fluticasone propionate is <2%, and oral bioavailability is <1%. Intranasal exposure results in the majority of the dose being swallowed. Topical absorption of fluticasone propionate is very low but can change depending on a number of factors including integrity of the skin and the presence of inflammation or disease. A study of 24 healthy Caucasian males showed an inhaled bioavailability of 9.0%.
Toxicity
Fluticasone propionate's use in specific populations has not been well studied. Fluticasone propionate is not carcinogenic, mutagenic, or clastogenic, nor did it affect fertility in animal studies. Subcutaneous fluticasone propionate has been shown to produce teratogenic effects in rats though oral administration does not. Generally, there are no reported adverse effects with fluticasone in pregnancy. Fluticasone propionate in human milk may cause growth suppression, effects on endogenous corticosteroid production, or other effects. Pediatric patients treated with fluticasone propionate ointment experienced adrenal suppression. Geriatric patients treated with fluticasone propionate did not show any difference in safety or efficacy compared to other patient groups, though older patients may be more sensitive to adverse effects. There is no difference in the clearance of fluticasone propionate across genders or race. Patients with hepatic impairment should be closely monitored due to the elimination mechanism.
The Uses of Fluticasone propionate
Fluticasone Propionate is a derivative of Flumethasone, a glucocorticoid that has antiallergic, anti-asthmatic, and anti-inflammatory properties. It is used in the treatment of seasonal rhinitis and asthma. Compared to beclomethasone dipropionate, fluticasone propionate is reported to have a comparable side effect profile, but twice the activity in the treatment of asthma.
Background
Fluticasone propionate is a synthetic glucocorticoid. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications. Fluticasone propionate was first approved in 1990.
Indications
Fluticasone propionate is indicated as an inhaler for the treatment and management of asthma by prophylaxisas well as inflammatory and pruritic dermatoses. Fluticasone propionate nasal spray is indicated for managing allergic and nonallergic rhinitis.
What are the applications of Application
Fluticasone propionate is a high-affinity, selective glucocorticoid receptor agonist
Pharmacokinetics
Systemically, fluticasone propionate activates glucocorticoid receptors, and inhibits lung eosinophilia in rats. Fluticasone propionate as a topical formulation is also associated with vasoconstriction in the skin.
Metabolism
Fluticasone propionate is cleared from hepatic metabolism by cytochrome P450 3A4. Fluticasone propionate is hydrolysed at the FIVE-S-fluoromethyl carbothioate group, forming an inactive metabolite.
Properties of Fluticasone propionate
Melting point: | 275 °C |
Boiling point: | 568.3±50.0 °C(Predicted) |
Density | 1.32±0.1 g/cm3(Predicted) |
storage temp. | Store at RT |
solubility | DMSO: ≥10 mg/mL |
form | solid |
color | white |
Safety information for Fluticasone propionate
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P281:Use personal protective equipment as required. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Fluticasone propionate
InChIKey | WMWTYOKRWGGJOA-CENSZEJFSA-N |
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Jigs Chemical ltd
Micro Orgo Chem
Coral Drugs Pvt Ltd
Grefuel Private Limited
Vamsi Labs Ltd
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