1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
Synonym(s):EDC hydrochloride;EDC;EDAC;WSC hydrochloride;N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
- CAS NO.:25952-53-8
- Empirical Formula: C8H18ClN3
- Molecular Weight: 191.7
- MDL number: MFCD00044916
- EINECS: 247-361-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-19 20:05:26
![1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Structural](https://img.chemicalbook.in/CAS/GIF/25952-53-8.gif)
What is 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride?
The Uses of 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is water-soluble carbodiimide, widely used for peptide coupling.
What are the applications of Application
EDC hydrochloride is a water soluble carboxyl activating carbodiimide reagent, used for amide bond formation.
Description
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC or EDAC) is a zero-length crosslinking agent to couple carboxyl groups to primary amines. This crosslinker has been used in diverse applications such as forming amide bonds in peptide synthesis, attaching haptens to carrier proteins to form immunogens, labeling nucleic acids through 5' phosphate groups, and creating amine-reactive NHS-esters of biomolecules. EDC reacts with a carboxyl to form an amine-reactive O-acylisourea intermediate. If this intermediate does not encounter an amine, it will hydrolyze and regenerate the carboxyl group. In the presence of N-hydroxysulfosuccinimide (Sulfo-NHS), EDC can be used to convert carboxyl groups to amine-reactive Sulfo-NHS esters. This is accomplished by mixing the EDC with a carboxyl-containing molecule and adding Sulfo-NHS.
Properties of 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
Melting point: | 110-115 °C(lit.) |
Density | 0.877 g/mL at 20 °C(lit.) |
storage temp. | -20°C |
solubility | H2O: soluble1 gm/10 ml, clear to very slightly hazy, colorless to very faintly yellow |
form | Crystalline Powder |
color | White to off-white |
Water Solubility | Soluble |
Sensitive | Hygroscopic |
Safety information for 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
Signal word | Danger |
Pictogram(s) |
![]() Skull and Crossbones Acute Toxicity GHS06 ![]() Health Hazard GHS08 ![]() Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H311:Acute toxicity,dermal H315:Skin corrosion/irritation H317:Sensitisation, Skin H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
InChIKey | FPQQSJJWHUJYPU-UHFFFAOYSA-N |
Abamectin manufacturer
R SCIENTIFIC
VGS SYNTHESIS PRIVATE LIMITED
SAGAR LIFE SCIENCES PVT LTD
HEMA PHARMACEUTICALS PVT LTD
LIFECHEM PHARMA
SURVIVAL TECHNOLOGIES LIMITED
Aptus Therapeutics
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